Galvus Met Overdosage

Signs and symptoms: Vildagliptin: Oedema and muscle pain were dose-limited in clinical studies. At 600 mg, one subject experienced oedema of the hands and feet, and an excessive increase in creatine phosphokinase (CPK) levels, accompanied by elevated levels of aspartate aminotransferase (AST), C-reactive protein and myoglobin. Three additional subjects in this dosage group presented with oedema of both feet, accompanied by paraesthesia in two cases. All symptoms and laboratory abnormalities resolved after study-drug discontinuation.
In case of overdosage, the medicinal product should be withdrawn and the patient should be given symptomatic and supportive treatment.
Vildagliptin is not dialysable; the major hydrolysis metabolite can be removed by haemodialysis.
Metformin: Hypoglycaemia has not been seen even after extremely high metformin doses (up to 85 g), but lactic acidosis has occurred under such circumstances. Lactic acidosis is a medical emergency necessitating hospitalization (see Precautions). Both lactate and metformin are removed by haemodialysis.